Use of Colchicine in Dermatology
PDF
Cite
Share
Request
Review
P: 27-30
September 2020

Use of Colchicine in Dermatology

Dermatoz 2020;11(3):27-30
1. Midyat Devlet Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, Mardin, Türkiye
No information available.
No information available
Received Date: 08.12.2020
Accepted Date: 22.12.2020
Publish Date: 16.03.2021
PDF
Cite
Share
Request

ABSTRACT

Colchicine is an effective, easily accessible and safe drug that has been for many years. It has an antimitotic and anti-inflammatory effect. Studies have emphasized that colchicine is also an effective and well tolerated drug in dermatological diseases. This review will focus on the pharmacological properties of colchicine, its use in dermatology, its side effects and its use in special groups.

References

1
Dasgeb B, Kornreich D, McGuinn K, Okon L, Brownell I, Sackett DL. Colchicine: an ancient drug with novel applications. Br J Dermatol 2018; 178: 350-356.
2
Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of action of colchicine in the treatment of gout. Clin Ther 2014; 36: 1465-1479.
3
Ferron GM, Rochdi M, Jusko WJ, Scherrmann. Oral absorption characteristics and pharmacokinetics of colchicine in healthy volunteers after single and multiple doses. J Clin Pharmacol 1996; 36: 874-883.
4
Sardana K, Sinha S, Sachdeva S. Colchicine in dermatology: rediscovering an old drug with novel uses. Indian Dermatol 2020; 11: 693-700.
5
Mat MC. Treatment of behcet’s disease. Turkderm 2009; 43: 92-97.
6
Davatchi F, Sadeghi Abdollahi B, Tehrani Banihashemi A, et al. Colchicine versus placebo in Behçet’s disease: randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009; 19: 542-549.
7
Gupta R, Woodley DT, Chen M. Epidermolysis bullosa acquisita. Clin Dermatol 2012; 30: 60-69.
8
Kim JH, Kim YH, Kim SC. Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases. Acta Derm Venereol 2011; 91: 307-312.
9
Adachi A, Komine M, Suzuki M, et al. Oral colchicine monotherapy for epidermolysis bullosa acquisita: mechanism of action and efficacy. J Dermatol 2016; 43: 1389-1391.
10
Sais G, Vidaller A, Jucgla A, F Gallardo F, Peyrí J. Colchicine in the treatment of cutaneous leukocytoclastic vasculitis. Results of a prospective, randomized controlled trial. Arch Dermatol 1995;131:1399-1402.
11
Suehisa S, Tagami H, Inoue F, Matsumoto K, Yoshukini K. Colchicine in the treatment of acute febrile neutrophilic dermatosis (Sweet’s syndrome) Br J Dermatol 1983; 108: 99-101.
12
Mori S, Hino K, Izumi H. Clinical manifestations and treatment of pustulosis palmaris et plantaris. J Dermatol 1976; 86: 671-676.
13
Zachariae H, Kragballe K, Herlin T. Colchicine in generalized pustular psoriasis: clinical response and antibody-dependent cytotoxicity by monocytes and neutrophils. Arch Dermatol Res 1982; 274: 327-333.
14
Katz J, Langevitz P, Shemer J, Barak S, Livneh A. Prevention of recurrent aphthous stomatitis with colchicine: an open trial. J Am Acad Dermatol 1994; 31: 459-461.
15
Fontes V, Machet L, Huttenberger B, Lorette G Vaillant L. [Recurrent aphthous stomatitis: treatment with colchicine. An open trial of 54 cases]. Ann Dermatol Venereol 2002; 129:1365-1369.
16
Faghihi G, Elahipoor A, Iraji F, Behfar S, Abtahi-Naeini B. Topical colchicine gel versus diclofenac sodium gel for the treatment of actinic keratoses: a randomized, double-blind study. Adv Med 2016; 2016: 5918393. doi: 10.1155/2016/5918393.
17
Akar A, Taştan BH, Erbil H, Arca E, Kurumlu Z, Gür AR. Efficacy and safety assessment of 0.5% and 1% colchicine cream in the treatment of actinic keratoses. J Dermatolog Treat 2001; 12: 199-203.
18
Slobodnick A, Shah B, Pillinger MH, Krasnokutsky S. Colchicine: old and new. Am J Med 2015; 128: 461-470.