A Case of Methotrexate Intoxication Who Used Methotrexate for Plantar Lesions on Recommendation by Pharmacist
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Case Report
P: 99-102
September 2019

A Case of Methotrexate Intoxication Who Used Methotrexate for Plantar Lesions on Recommendation by Pharmacist

Dermatoz 2019;10(3):99-102
1. Sağlık Bilimleri Üniversitesi, Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi, Dermatoloji Kliniği, Ankara, Türkiye
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Received Date: 03.08.2019
Accepted Date: 23.08.2019
Publish Date: 24.09.2020
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ABSTRACT

Methotrexate is used in the treatment of psoriasis. Although, weekly low doses used in psoriasis, in the presence of renal deficiency, folic acid deficiency, elderly age or accidently use of high doses, methotrexate toxicity can be seen. Here we report a 48-year-old woman with metotrexate intoxication who used methotrexate tablets for her plantar lesions on recommendation by pharmacist. İnterstingly; because of she had discontinued medication before applied to our clinic, her clinical symptoms are mild and we treated her only folic acid. By presenting the case we also want to emphasize that drugs which should be used with precautions should not be sold without prescription.

References

1Warren RB, Weatherhead SC, Smith CH, et al. British association of Dermatologists’ guidelines for the safe and effective prescribing of methotrexate for skin disease 2016. Br J Dermatol 2016; 175: 23-44.
2Mrowietz U, de Jong EM , Kragballe K, et al. A consensus report on appropriate treatment optimization and transitioning in the management of moderate to severe plaque psoriasis. J Eur Acad Dermatol Venereol 2014; 28: 438-453.
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4Bookstaver PB, Norris L, Rudisill C, DeWitt T, Aziz S, Fant J. Multiple toxic effects of low dose methotrexate in a patient treated for psoriasis. Am J Health Syst Pharm 2008; 65: 2117-2121.
5Shaikh N, Sardar M, Raj R, Jariwala P. A rapidly fatal case of low-dose methotrexate toxicity. Case Rep Med 2018; 2018: 9056086.
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